Muscadine Health Benefits — Links to Scientific Research Papers

These abstracts and articles are grouped informally by subject area, and are listed alphabetically by title. Year of publication is bold, to assist those seeking to review the most recent articles. Recently added links have the date of publication in red.

Diabetes and Obesity

Inhibition of protein glycation by skins and seeds of
the muscadine grape. Farrar JL et al.  Biofactors. 2007; 30(3):193-200.

Inhibitory effects of muscadine anthocyanins on α-glucosidase and pancreatic lipase activities. J Agric Food Chem. You Q et al. 2011 Sep 14;59(17):9506-11.

Muscadine grape (Vitis rotundifolia) and wine phytochemicals prevented obesity-associated metabolic complications in C57BL/6J mice. Gourineni V, Shay NF, Chung S, Sandhu AK, Gu L. J Agric Food Chem. 2012 Aug 8;60(31):7674-81.

Muscadine grape products intake, diet and blood constituents of non-diabetic and type 2 diabetic subjects. Banini AE et al. Nutrition. 2006 Nov-Dec;22(11-12):1137-45.

Muscadine grape seed oil as a novel source of tocotrienols to reduce adipogenesis and adipocyte inflammation. Zhao L et al. Food Funct. 2015 Jul;6(7):2293-302.


A polyphenol-rich muscadine grape extract inhibits HER + Breast Cancer and protects against trastuzumab-induced cardiotoxicity. Mackert J., Gallagher P.E. and Tallant E. 2020. Current Development in Nutrition 4 (Suppl2):334.

Anticancer effects of four varieties of muscadine grape. God JM et al. J Med Food. 2007 Mar;10(1):54-9.

The Anticancer and Antioxidant Effects of Muscadine Grape Extracts on Racially Different Triple-negative Breast Cancer Cells.  Mendonca P, Darwish AG, Tsolova V, El-Sharkawy I, Soliman KFA.  Anticancer Res. 2019 Aug;39(8):4043-4053

CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-α) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE).  Burton LJ, Hawsawi O, Sweeney J, Bowen N, Hudson T, Odero-Marah V.  PLoS One. 2019 Apr 9;14(4):e0214844.

The comparative study among different fractions of muscadine grape ‘Noble’ pomace extracts regarding anti-oxidative activities, cell cycle arrest and apoptosis in breast cancer.  Luo J, Song S, Wei Z, Huang Y, Zhang Y, Lu J.  Food Nutr Res. 2017 Dec 10;61(1):1412795.

Effects of phenolic compounds in blueberries and muscadine grapes on HepG2 cell viability and apoptosis. Weiguang Y et al. Food Research International 2006 39(5).

Extracts from red muscadine and cabernet sauvignon wines induce cell death in MOLT-4 human leukemia cells. Mertens-Talcott SU et al. Food Chem. 2008 Jun 1;108(3):824-32.

Induction of cell death in Caco-2 human colon carcinoma cells by ellagic acid rich fractions from muscadine grapes (Vitisrotundifolia). Mertens-Talcott SU et al. J Agric Food Chem. 2006 Jul 26;54(15):5336-43.

Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms. Hudson TS et al. Cancer Res. 2007 Sep 1;67(17):8396-405.

Inhibition of prostate tumor growth by an extract from the muscadine grape. Gallagher P.E. and Tallant E.A. 2017. Abstract 1591AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. DOI: 10.1158/1538-7445.AM2017-1591.

Muscadine grape extract reduces lung and liver metastasis in mice and triple negative breast cancer in association with changes in the gut microbiome. Collard M., Tallant E.A. and Gallagher P.E. 2019. (P05-017-19). Current Developments in Nutrition 3(Supp1). nzz030.P05-017-19

Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells. Burton LJ et al. Carcinogenesis. 2015 Sep;36(9):1019-27.

Muscadine grape skin extract inhibits prostate cancer cells by inducing cell-cycle arrest, and decreasing migration through heat shock protein 40.  Ignacio DN, et al.  Heliyon. 2019 Jan 16;5(1):e01128

Muscadine grape skin extract reverts snail-mediated epithelial mesenchymal transition via superoxide species in human prostate cancer cells. Burton LJ et al. BMC Complement Altern Med. 2014 Mar 12;14:97.

Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis.  Burton LJ, et al.  PLoS One. 2016 Oct 18;11(10):e0164115.

Muscadine Grape Skin Extract (MPX) in Men with Biochemically Recurrent Prostate Cancer: A Randomized, Multicenter, Placebo-Controlled Clinical Trial.  Paller CJ, et al. Clin Cancer Res. 2018 Jan 15;24(2):306-315.

Phase I study of  muscadine grape extract in advanced malignancy. Rhonda L. Bitting,, et al.  2018. Journal of Clinical Oncology. This phase I study (NCT02583269) assessed safety and tolerability of a proprietary MGE in patients (pts) with advanced solid tumors.

A phase I study of muscadine grape skin extract in men with biochemically recurrent prostate cancer: Safety, tolerability, and dose determination. Paller CJ et al. Prostate. 2015 Oct;75(14):1518-25.

Phenolic Fractions from Muscadine Grape “Noble” Pomace can Inhibit Breast Cancer Cell MDA-MB-231 Better than those from European Grape “Cabernet Sauvignon” and Induce S-Phase Arrest and Apoptosis.  Luo J, et al.  J Food Sci. 2017 May;82(5):1254-1263

Study of anticancer activities of muscadine grape phenolics in vitro. Yi W, et al J Agric Food Chem. 2005 Nov 2;53(22):8804-12..

Gut Health

Activities of muscadine grape skin and quercetin against Helicobacter pylori infection in mice. Brown JC et al. J ApplMicrobiol. 2011 Jan;110(1):139-46.

Antibacterial effects of grape extracts on Helicobacter pylori. Brown JC et al.  Appl Environ Microbiol. 2009 Feb;75(3):848-52.

Muscadine Grape (Vitis rotundifolia) or Wine Phytochemicals Reduce Intestinal Inflammation in Mice with Dextran Sulfate Sodium-Induced Colitis. Li R et al. J Agric Food Chem. 2017 Feb 1;65(4):769-776

Understanding the Phenolics in Muscadines

Antioxidant, antibacterial, and antibiofilm properties of polyphenols from muscadine grape (VitisrotundifoliaMichx.) pomace against selected foodborne pathogens. Xu C et al. J Agric Food Chem. 2014 Jul 16;62(28):6640-9.

Antioxidant capacity, phenolic content, and profiling of phenolic compounds in the seeds, skin, and pulp of Vitisrotundifolia (Muscadine Grapes) as determined by HPLC-DAD-ESI-MS(n). Sandhu AK and Gu L. J Agric Food Chem. 2010 Apr 28;58(8):4681-92.

Application of muscadine grape (VitisrotundifoliaMichx.) pomace extract to reduce carcinogenic acrylamide. Xu C et al. Food Chem. 2015 Sep 1;182:200-8.

Ellagic acid and flavonoid antioxidant content of muscadine wine and juice. Talcott ST and Lee JH. J Agric Food Chem. 2002 May 22;50(11):3186-92.

Evaluation of phenolic compounds, antioxidant and antiproliferative activities of 31 grape cultivars with different genotypes.  Xia L, et al.  J Food Biochem. 2019 Jun;43(6):e12626.

High-performance liquid chromatography-mass spectrometry and evaporative light-scattering detector to compare phenolic profiles of muscadine grapes. You Q et al. J Chromatogr A. 2012 Jun 1;1240:96-103.

Major flavonoids in grape seeds and skins: antioxidant capacity of catechin, epicatechin, and gallic acid. Yilmaz Y and Toledo RT. J Agric Food Chem. 2004 Jan 28;52(2):255-60.

Polyphenolics in grape seeds-biochemistry and functionality. Shi J et al. J Med Food. 2003 Winter;6(4):291-9.

Heart Health (including heart damage due to chemotherapy)

Effect of muscadine grape seed supplementation on vascular function in subjects with or at risk for cardiovascular disease: a randomized crossover trial. Mellen PB et al. J Am Coll Nutr. 2010 Oct;29(5):469-75.

Muscadine grape extract prevents cardiac cell cytotoxicity due to oxidative stress by enhancing mitochondrial function. Soto-Pantoja D.R., Tallant E.A. and Gallagher P.E. 2019. Abstract P2007: Hypertension 74:AP2007.

The effect of a muscadine grape extract on Angiotensin II induced hypertension and cardiac damage. Patil P., Gallagher P.E. and Tallant E.A. 2016. Abstract P166: Hypertension 68:AP166.


Enhancement of resistance to coccidiosis and necrotic enteritis in broiler chickens by dietary muscadine pomace. McDougald LR et al. Avian Dis. 2008 Dec;52(4):646- 51.

Fatty acid composition, oxidative stability, antioxidant and antiproliferative properties of selected cold-pressed grape seed oils and flours. Lutterodt H et al. Food Chem. 2011 Sep 15;128(2):391-9.

Inactivation of Enterobactersakazakii by water-soluble muscadine seed extracts. Kim TJ et al. Int J Food Microbiol. 2009 Feb 28;129(3):295-9.

Ocular inflammation and endoplasmic reticulum stress are attenuated by supplementation with grape polyphenols in human retinal pigmented epithelium cells and in C57BL/6 mice.  Ha JH, et al. J Nutr. 2014 Jun;144(6):799-806.

Polyphenolics from açaí( Euterpe oleracea Mart.) and red muscadine grape (Vitisrotundifolia ) protect human umbilical vascular Endothelial cells (HUVEC) from glucose- and lipopolysaccharide (LPS)-induced inflammation and target microRNA-126. Noratto GD et al. J Agric Food Chem. 2011 Jul 27;59(14):7999-8012.